Regulation of Telomerase Activity
The literature data on the regulation of the telomerase activity are systemized. The structure and functions of telomeres and telomerase are described. The main ways of epigenetic regulation of the telomerase activity – the modification of TERT gene histone and its methylation – are described. Particular attention is paid to the regulation of the telomerase activity at the transcriptional level (transcriptional activators and inhibitors of TERT, as well as two-way regulators of transcription) and post-transcriptional regulation (alternative splicing of TERT mRNA, phosphorylation, and ubiquitination of TERT).
Keywords: теломеры, теломераза, регуляция активности, функции теломеразы, гены теломеразного комплекса.